The “Immortality Enzyme”: Human Telomerase Holoenzyme as a potential anti-cancer therapeutic target

By Alice Barocco Human Telomerase Holoenzyme, most known as Telomerase and often regarded as the “Immortality enzyme”, is a cellular reverse transcriptase comprised of protein subunits and RNA.1 The enzyme can be pictured as a molecular motor: its role is to add new stretches of DNA, more specifically a “TTAGGG” sequence, onto the ends ofContinue reading The “Immortality Enzyme”: Human Telomerase Holoenzyme as a potential anti-cancer therapeutic target

Advancements in cancer immunotherapies: CAR-T cell technology

By Yuki Agarwala We encounter over 60,000 germs every day, yet we do not find ourselves falling sick every day due to the efficiency of our immune system.1 We have an innate and adaptive immune system – the innate response is a general reaction that occurs early during infections, whereas the adaptive response is antigen-specificContinue reading “Advancements in cancer immunotherapies: CAR-T cell technology”

The role of the gut microbiota in Alzheimer’s disease

By Michelle Lam Alzheimer’s disease (AD) is the leading cause of dementia, affecting over 50 million people worldwide.1 With improvements in global health, dementia cases are projected to triple by 2050.2 Despite advancements in understanding disease progression, there are still no disease-modifying therapies available. Therefore, it is crucial that new biomarkers are identified to overcomeContinue reading The role of the gut microbiota in Alzheimer’s disease

What is the PICA disorder?

By Anushka Gupta You have probably heard of anorexia nervosa as the most common eating disorder, but do you know what PICA is? According to NEDA (National Eating Disorders Association), it is “eating items that aren’t typically thought of as food and have no significant nutritional value”.1 It is hugely prevalent as it can affectContinue reading What is the PICA disorder?

How sea sponges could be the answer to antibiotic resistance

By Madeleine Eaton In the past century, antimicrobial resistance (AMR) has emerged as a critical global public health threat, threatening our ability to prevent and treat infections ranging from bacterial to fungal. AMR develops in microorganisms due to many reasons including drug efflux pumps, antibiotic inactivation by enzymes, and alterations in metabolic pathways or cellContinue reading How sea sponges could be the answer to antibiotic resistance

Bipolar disorder 

By Gio Chang  Bipolar disorder is a condition which all of us have probably heard about but don’t understand very much about. Many people think of them simply as mood swings that we experience in our day to day lives. However, it is a type of mental illness that, surprisingly, impacts quite a large portion of populations. In fact, around 2.8% of theContinue reading “Bipolar disorder “

Nanoparticle-based drug delivery in cancer therapy

By Martina Torcè Innovative drug delivery systems are important in the development of cancer therapy due to the need for precise and contained targeting of the cancerous tissue. The chemotherapeutic agents usually contained in cancer drugs are often delivered non-specifically, which ends up causing high toxicity for the surrounding healthy cells and resulting in lowContinue reading Nanoparticle-based drug delivery in cancer therapy

The development of quantitative structure-metabolism relationships for drug discovery and safety

By Andrea Flores Esparza and Karishma Krishna  In 2020, more than 2.5 million animals were used in scientific research in the UK.1 Use of animals in pharmaceutical development pipelines poses significant ethical, financial, and translational challenges and there is an urgent need for technologies that facilitate efficient drug discovery whilst reduce the need for animalContinue reading “The development of quantitative structure-metabolism relationships for drug discovery and safety”

Crizanlizumab – the new drug that will change the lives of sickle cell disease patients

By Iulia Kis Sickle cell disease (SCD) is the most common inherited blood-related disease, presenting in an estimated 20-25 million people.1 SCD significantly reduces the quality of life of affected patients due to its characteristic presence of sickle haemoglobin (HbS) leading to conditions such as vaso-occlusive crises (crises related to SCD-related pain), organ dysfunction andContinue reading “Crizanlizumab – the new drug that will change the lives of sickle cell disease patients”

Unlocking further potential of current clinical drugs with biased agonists and allosteric modulators

By Kilian Robinson GPCR’s are transmembrane proteins that are involved in a multitude of physiological processes and therefore have been attractive targets for drugs in recent years. In fact, approximately 34% of drugs passed by the FDA work to target GPCR’s and these include some of the most important clinically used drugs, such as antihistaminesContinue reading “Unlocking further potential of current clinical drugs with biased agonists and allosteric modulators”