Digital Twins

By Naveesha Karunanayaka The idea of a digital twin holds different meanings across many sectors. Within Healthcare, creating a ‘digital twin’ involved curating a genetic profile of an individual which can then be used for medical purposes. This digital ‘self’ of an individual can then be used for drug and therapy testing – with suchContinue reading “Digital Twins”

Organ regeneration with 3D printing, and future applications 

By Jenny Tang Organ regeneration is best defined as the regrowth of lost tissues or organs in the response to injury. It is a naturally occurring phenomenon in certain organisms, but in humans only few organs such as the liver and skin are known to be able to redevelop. Through artificial means however, we canContinue reading Organ regeneration with 3D printing, and future applications 

The present and future of tissue engineering 

By Pia Skok Tissue engineering is a rapidly evolving field, aiming to repair, replace, or regenerate damaged tissues. By combining cells from the body with highly porous scaffold biomaterials, which act as templates interacting with the cells and influencing their behaviour, it enables new tissue growth.1   There are two main approaches which are currently utilized to produce engineered tissues. First, scaffolds can be built from scratch from different biomaterials including ceramics, synthetic polymers, and natural polymers 1. Upon introduction of cells with or without theContinue reading The present and future of tissue engineering “

Desorption electrospray ionisation mass spectrometry imaging

By Haoyu Li Desorption electrospray ionisation (DESI) technique, invented by Takás et al in 2004, allowed ambient mass spectrometry (MS) analysis under room conditions.1 It offered a solution to the issue faced in traditional MS where samples had to be introduced into a vacuum or into an inaccessible region closely coupled with a vacuum system.1Continue reading Desorption electrospray ionisation mass spectrometry imaging

DNA Hard drives- a new way to store and read data, what are they and what could they be used for?

By Jenny Tang    DNA Hard drives (DNA-HD) are based off DNA nanotechnology and nano pores which are achieved by reading molecules, one by one per millisecond using nanopores. This is done by annealing 7228 nucleotides stranded DNA, creating a scaffold. Taking advantage of the negative charge of DNA, it can be read by nanoporeContinue reading DNA Hard drives- a new way to store and read data, what are they and what could they be used for?

Next Generation Sequencing

By Mark Comer The development of Sanger sequencing in 1977 laid the foundation for DNA sequencing technologies and continued to be the leading technique for the discovery of DNA sequences until the 1990s.  With the genome of a bacteriophage the first to be sequenced in the same year, sequencing technology continued to be developed. ReplacingContinue reading “Next Generation Sequencing”

AlphaFold 2: Unfolding the Future of Predicting Protein Structures

By Audrey Ko Proteins are macromolecules that are essential for many biological functions within our body. The specific function of a protein depends on its unique 3D structure which is the result of folding of a chain or chains of amino acids. For the past decades, researchers have developed different experimental techniques for determining theContinue reading “AlphaFold 2: Unfolding the Future of Predicting Protein Structures”

Detect-seq: A Tool for Evaluating Gene Editing technologies

By Chi Wai (Jessie) Ng The ethics crisis of 2018 surrounding the birth of two genetically edited twin girls, Lulu and Nana,  raised enormous medical practice concerns and sparked outcry from all across the globe. Aside from ethical concerns, the subject matter of gene editing on humans is so sensitive because the genetically modified twinsContinue reading “Detect-seq: A Tool for Evaluating Gene Editing technologies”

DNA Encoded Data: A Replacement for Hard Drives?

By Nick Bitterlich We all own that one hard drive that stores our fondest memories in an intricate network of chips. It writes and rewrites data multiple times whenever we save or download files. It seems USBs and hard drives can’t have enough storage with the tremendous amounts of data generated on a daily basis.Continue reading “DNA Encoded Data: A Replacement for Hard Drives?”

How can graphs help us solve problems underpinning biology?

By Anjali Samra To understand biological processes, knowledge about molecules and the relationships between them is required. For example, graphs can be used to model protein to protein binding interactions within different molecular pathways and so they can be used to investigate the relationships between different structures and their properties. This is particularly important inContinue reading “How can graphs help us solve problems underpinning biology?”