Autophagy and its role in Cancer

By Clarice Tse The discovery of autophagy and its mechanism in action was elucidated by Yoshinori Ohsumi in the 1990s. As years passed, the expansion of knowledge in autophagy such as its role and function in bioenergetic homeostasis and host defense, and its impact in the study of human health and disease, has put thisContinue reading “Autophagy and its role in Cancer”

A Poorer Perspective: The Prominence of Publication Bias

By Ethan Sim Empiricism and objectivity undergird the reliability of scientific research (Nature Medicine, 2001) by inspiring investigative and publicatory rigour (Prager et al., 2018). However, the nexus between significant results and career progression (Joober et al., 2012) creates publication bias: an incentive to prioritise such results for publication, which ultimately undermines scientific progress (NatureContinue reading “A Poorer Perspective: The Prominence of Publication Bias”

Applying Deep Learning Towards Cancer Prognosis

By Ayoush Srivastava The earliest record of cancer was found in a trauma surgery textbook from ancient Egypt; it described that for the disease, “there is no treatment” (ACS Medical Content, Editorial, and News Staff, 2014). Thousands of years later, cancer remains a formidable force, causing one-sixth of deaths across the globe (Zhu et al.,Continue reading “Applying Deep Learning Towards Cancer Prognosis”

Reducing methane emissions from rice cultivation

By Malini Williams Rice is one of the most important crops in the world, representing an essential staple in the diets of billions of people around the world. It represents one-fifth of the calories consumed worldwide and is grown on more than 140 million hectares (Hawken, 2017; Wassman, Hosen, & Sumfleth, 2009). However, rice cultivationContinue reading “Reducing methane emissions from rice cultivation”

The dorsal-ventral axis and why some organisms are upside-down

By Heiloi Yip Developmental biologists have long since been investigating how bilaterian organisms are able to generate complex three-dimensional shapes from a small sphere of cells that some call the embryo. Clearly, a massive amount of coordination is required between each cell to generate such shapes. For example, the cells need to know where theyContinue reading “The dorsal-ventral axis and why some organisms are upside-down”

Can nutrigenomics serve up the perfect diet?

By Ellie Fung While it is disputed whether Hippocrates had ever uttered “let food be thy medicine”, there is no denying that food is inextricably linked to health. More recently, it was recognised that food can induce different responses in different individuals, and a subset of the population can benefit from a certain food thatContinue reading “Can nutrigenomics serve up the perfect diet?”

AAV-Induced Cancer: Cause for Concern in Gene Therapy?

By Charlotte Hutchings Gene therapy is an approach to treating or preventing human disorders through the delivery of therapeutic nucleic acids to diseased cells (Lundstrom, 2018). In order to achieve targeted delivery to specific organs and cell types, viruses have been employed as a gene therapy vector as they have naturally evolved to be ableContinue reading “AAV-Induced Cancer: Cause for Concern in Gene Therapy?”

How the gut microbiota affects neurological disorders: An Insight into Parkinson’s Disease

By Yuki Agarwala Our gut is home to approximately 100 trillion bacteria, both good and bad, which are collectively known as the gut microbiota (Can gut bacteria, 2016). This represents 10 times the number of cells in the human body, and a stunning 3 million genes. Interestingly, only around 1~3% of these bacteria are commonContinue reading “How the gut microbiota affects neurological disorders: An Insight into Parkinson’s Disease”

Plant-Based Meat: Hype or Health Hero?

By Anushka Gupta The psychological illusion of a soy nugget being ‘dressed up’ as a beef patty encapsulates the worldwide trend of plant-based meat. There has been a recent surge in the drive towards being healthy through a high protein less fat diet in which the idea of plant-based meat stemmed from.  Fast-food chains likeContinue reading “Plant-Based Meat: Hype or Health Hero?”