Gene therapy for Parkinson’s disease: a way forward?

By Elisa Botting Parkinson’s disease is a neurodegenerative disorder with no current cure. The disease results in the loss of neurons responsible for the release of dopamine (termed dopaminergic neurons) in the substantia nigra – a region of the brain’s basal ganglia which is important for movement¹ . Its progressive nature means that symptoms likeContinue reading Gene therapy for Parkinson’s disease: a way forward?

The gut bacteriome and virome in Covid-19 patients

By Madeleine Pramoedya The bacteriome itself presents a subset of the microbiome which exclusively consists of bacteria. It is the most widely studied and characterised aspect of the gut microbiome.1 It has also long been suggested that the composition of the gut microbiome influences host physiology and plays a strong role in modulating the host’sContinue reading “The gut bacteriome and virome in Covid-19 patients”

Updates and new insights into gastroparesis

By Shiyi Liang Gastroparesis (GP) is a chronic situation when patients suffer from slow and abnormal gastric emptying, which means food could not be passed on to the intestine at normal speed. It is characterised by symptoms of early satiety, bloating, abdominal pain, vomiting, and heartburn.1 Based on a study from Minnesota in 2007, theContinue reading “Updates and new insights into gastroparesis”

Why do honeybee queens live longer than their workers?

By Heiloi Yip Honeybees are well-known for their social hierarchy being consisted of two main castes: the queens and the female workers (the male drones will be ignored in this article). Each colony will typically consist of a single egg-laying queen, along with tens of thousands of workers that perform various tasks to maintain theContinue reading “Why do honeybee queens live longer than their workers?”

The role of the gut microbiota in Alzheimer’s disease

By Michelle Lam Alzheimer’s disease (AD) is the leading cause of dementia, affecting over 50 million people worldwide.1 With improvements in global health, dementia cases are projected to triple by 2050.2 Despite advancements in understanding disease progression, there are still no disease-modifying therapies available. Therefore, it is crucial that new biomarkers are identified to overcomeContinue reading The role of the gut microbiota in Alzheimer’s disease

How sea sponges could be the answer to antibiotic resistance

By Madeleine Eaton In the past century, antimicrobial resistance (AMR) has emerged as a critical global public health threat, threatening our ability to prevent and treat infections ranging from bacterial to fungal. AMR develops in microorganisms due to many reasons including drug efflux pumps, antibiotic inactivation by enzymes, and alterations in metabolic pathways or cellContinue reading How sea sponges could be the answer to antibiotic resistance

Bipolar disorder 

By Gio Chang  Bipolar disorder is a condition which all of us have probably heard about but don’t understand very much about. Many people think of them simply as mood swings that we experience in our day to day lives. However, it is a type of mental illness that, surprisingly, impacts quite a large portion of populations. In fact, around 2.8% of theContinue reading “Bipolar disorder “

Crizanlizumab – the new drug that will change the lives of sickle cell disease patients

By Iulia Kis Sickle cell disease (SCD) is the most common inherited blood-related disease, presenting in an estimated 20-25 million people.1 SCD significantly reduces the quality of life of affected patients due to its characteristic presence of sickle haemoglobin (HbS) leading to conditions such as vaso-occlusive crises (crises related to SCD-related pain), organ dysfunction andContinue reading “Crizanlizumab – the new drug that will change the lives of sickle cell disease patients”

How plants defend themselves

By Justin Bauer In the 350 million years that plants and insects have coexisted, both have evolved strategies to avoid each other’s defense systems. Plants have developed an elegant defense system that can recognize foreign molecules or damaged cells that activate the immune response.1 Plants have two main forms of defense: direct defense and indirectContinue reading “How plants defend themselves”

Ambrosia and the Promise of Young Blood

By Isabelle Hall In 2016, Ambrosia was founded by Jesse Karmazin. The start-up sought to provide transfusions of blood plasma from people aged 16-25 to patients over 35, at a cost of $8000 per litre. Karmazin claimed that the transfusions had led to positive changes in his clients, appearing to reduce the burden of certainContinue reading “Ambrosia and the Promise of Young Blood”