miRNA: interaction between the host and the virus

By Ashley Lai The interaction between host cell miRNAs and the virus is vital for virus pathogenesis. MicroRNAs (miRNAs) are short non-coding RNAs that regulate the protein expression by mRNA cleavage, degradation and hence repressing their translation (Wahid et al., 2010). Therefore during infections, cellular miRNAs are also involved in regulating their immune response andContinue reading “miRNA: interaction between the host and the virus”

Autoimmunity: Why does your body attack your own cells?

By MingMing Yang Our immune system is complex and vital for our survival. Unlike other body systems, it is pervasive, spreading throughout our body involving many kinds of cells, organs, and tissues (The immune system: Cells, tissues, function, and disease., 2018). In normal conditions, it recognizes invading pathogens and damaged cells in our body, mountingContinue reading “Autoimmunity: Why does your body attack your own cells?”

CBD: is it worth the high-pe?

By Shivani Raja Cannabidiol (CBD) is one of over 120 cannabinoids found in the plant cannabis sativa, from which the drug cannabis can also be produced. Whilst cannabis usage is illegal in the UK, CBD is a legal cannabis sativa isolate which has garnered interest for its therapeutic uses. CBD has been reported to treatContinue reading “CBD: is it worth the high-pe?”

The Angiogenic Switch

By Mark Comer Sustained angiogenesis is one of the six hallmarks of cancer, presented in the seminal publication by Hanahan & Weingberg in 2000. The ‘switch’ refers to a distinct event during cancer progression where the tumour microenvironment is altered to support growth of new vasculature. The exact steps and pattern of vascularisation are diverseContinue reading “The Angiogenic Switch”

Understanding the skin’s circadian rhythm and metabolome

By Yeji Hong Circadian rhythms, which are 24-hour oscillations in behaviour and physiology, play a role in the function of all cells in the body to optimize cellular functions to adapt to environmental challenges throughout the day. Visible light is considered as the most powerful ‘master’ clock to act upon humans, through the retina. TheContinue reading “Understanding the skin’s circadian rhythm and metabolome”

Benefits of exercise in Alzheimer’s disease

By Sarah Choi With lockdown, quarantine, and the pandemic having continued for more than a year, many have been unable to go to the gym, and have had much less opportunity for physical activity. However, while people may be spending an unprecedented amount of time indoors nowadays, the popularisation of exercising at home has providedContinue reading “Benefits of exercise in Alzheimer’s disease”

The Making of Three-Parent Babies

By Cristina Riquelme Vano Where does a baby from? The answer used to be quite simple; the fertilization of the paternal sperm and the maternal ovum gives rise to a new-born baby nine months later. However, recent medical advances have challenged this question. What if a baby could come from three parents instead of two?Continue reading “The Making of Three-Parent Babies”

Could humans ever become cancer resistant?

By Aaruni Arora A certain species of rodents with pink, wrinkled, hairless skin and buck teeth can be somewhat idealised as the supermodels of all animal models. Heterocephalus glaber, more commonly known as the Naked Mole Rat, is of interest to humans because of their very strange qualities. To begin with, these native East AfricanContinue reading “Could humans ever become cancer resistant?”

The Guardian of the Genome in the Road to Cancer

By Michelle Lam Central to maintaining genome stability, tumour suppressor p53 has earned its title of the ‘Guardian of the Genome’. Over half of human cancers are reported to have mutations in the gene encoding p53, TP53, thus making it an appealing target for cancer therapy (Toshinori et al., 2011). With the majority of tumourContinue reading “The Guardian of the Genome in the Road to Cancer”

Novel Insights Into Phosphatidylinositol-mediated Oncogenesis

By Kelly Macdonald-Ramsahai  Lipids are organic molecules with diverse and fundamental biological roles in living cells. For example, lipids are signalling messengers, energy depots, molecular markers and dominate biological membranes. Through these roles, lipid species and related homeostatic pathways orchestrate highly regulated signaling pathways, which coordinate cellular events including cell cycle progression, apoptosis, survival andContinue reading “Novel Insights Into Phosphatidylinositol-mediated Oncogenesis”