New findings on the genetic factors behind Schizophrenia and Autism

By Clarice Tse Psychiatric and developmental disorders are often long-lasting if not life-long diseases that impact not only the sufferers but also their friends and families. Unlike infectious diseases or chronic diseases that may be cured, mental and developmental disorders are the hardest tackle, as the cause and origin of these diseases depends on multipleContinue reading “New findings on the genetic factors behind Schizophrenia and Autism”

iPS cells and their importance in the future medical field

By MingMing Yang The 2012 Nobel Prize in Physiology or Medicine was jointly awarded to John B. Gurdon and Shinya Yamanaka, for the discovery that mature cells can be reprogrammed to become pluripotent. This was when the phrase induced pluripotent stem (iPS) cells came into researchers’ attention. Gurdon’s investigations, using frog models back in 1962,Continue reading “iPS cells and their importance in the future medical field”

Glycogen phosphorylase and its relation to type 2 diabetes

By Jenny Tang     Glycogen phosphorylase is an enzyme that catalyzes the breakdown of glycogen to glucose-1-phosphate, where it then enters the glycolysis cycle. It releases glucose-1-phosphate from its terminal α-1,4 glycosidic bond (Livanova, 2002). It is highly regulated, by the phosphorylation, through a kinase cascade that occurs in the liver.  Regulation of glycogen phosphorylase  TheContinue reading “Glycogen phosphorylase and its relation to type 2 diabetes”

Deepmind’s Fifty-Year Breakthrough with Protein Folding

By Harit Phowatthansathian Deepmind, a Google subsidiary, has just unveiled its revolutionary AlphaFold 2 algorithm during the 14th Critical Assessment of Techniques for Protein Structure Competition (CASP14). The overarching goal of CASP14 is to develop an efficient, accurate algorithm for 3D protein structure modeling, under a competitive environment (CASP14, 2020). Teams are provided with multipleContinue reading “Deepmind’s Fifty-Year Breakthrough with Protein Folding”

Uncovering the Secret Behind Body Odour

By Anna Huang Like everyone’s genetic makeup, body odour emitted by each individual human is unique to them and is sometimes referred to as ‘odour signature’. Although the word ‘odour’ is mostly associated with a repulsive scent, body odour per se does not smell unpleasant. In fact, body odour and olfactory perception of other humanContinue reading “Uncovering the Secret Behind Body Odour”

Uncovering the meat-allergy mystery with ticks

By Linya Thng  Understanding the immunological basis of allergies remains a big question within the immunology community, especially when it comes to understanding the unique allergy towards mammalian meat. These allergies can be triggered by some of the unlikeliest creatures on the planet; one that most wouldn’t cross even the most accomplished minds in immunologyContinue reading “Uncovering the meat-allergy mystery with ticks”

Role of epigenetics in Type 2 diabetes

By Lai, Cheuk Epigenetics is the study of the inheritable changes in gene expression without any change to the DNA sequence. (Dupont, Armant & Brenner, 2009) It has been found to drive the development and pathogenesis of Type 2 Diabetes (T2D). T2D is a common disease affecting 422 million people worldwide due to a combinationContinue reading “Role of epigenetics in Type 2 diabetes”

Interferon-β and its use in the treatment of SARS-COV 2

By Kilian Robinson Amidst the coronavirus pandemic many people have looked towards vaccines to gain some hope that one day we may be able to control this disease. Yet, there may be other potential ways of treating and preventing coronavirus. One such potential solution is the antiviral action of interferons and how they can beContinue reading “Interferon-β and its use in the treatment of SARS-COV 2”

RNAi Therapies

By Mark Comer Ribonucleic acid interference (RNAi) is a process employed by cells to post-transcriptionally regulate gene expression. It relies on two types of RNA: microRNA (miRNA) and small-interfering RNA (siRNA). Synthetically produced versions of RNA molecules have shown great therapeutic promise for treating a variety of medical conditions including bacterial and viral infections, andContinue reading “RNAi Therapies”

Preterm girls and boys have different nutritional needs

By Yeji Hong Early nutrient intake and postnatal growth patterns closely relate to neurodevelopment outcomes and metabolic risk. There is increasing recognition that in addition to the quantity, quality of growth is important during the critical period for developmental programming. All infants are vulnerable to nutrition deficits, but infants of different sexes may have differentContinue reading “Preterm girls and boys have different nutritional needs”