Crizanlizumab – the new drug that will change the lives of sickle cell disease patients

By Iulia Kis Sickle cell disease (SCD) is the most common inherited blood-related disease, presenting in an estimated 20-25 million people.1 SCD significantly reduces the quality of life of affected patients due to its characteristic presence of sickle haemoglobin (HbS) leading to conditions such as vaso-occlusive crises (crises related to SCD-related pain), organ dysfunction andContinue reading “Crizanlizumab – the new drug that will change the lives of sickle cell disease patients”

Unlocking further potential of current clinical drugs with biased agonists and allosteric modulators

By Kilian Robinson GPCR’s are transmembrane proteins that are involved in a multitude of physiological processes and therefore have been attractive targets for drugs in recent years. In fact, approximately 34% of drugs passed by the FDA work to target GPCR’s and these include some of the most important clinically used drugs, such as antihistaminesContinue reading “Unlocking further potential of current clinical drugs with biased agonists and allosteric modulators”

The Use of Cannabinoids in Modern Medicine

By Sophie Blagg The Cannabis sativa plant has been used for medicinal and recreational purposes for many centuries, with the first evidence of use dating back to around 4,000 B.C. (Zuardi, 2006). During the 20th century the use of cannabis drastically reduced when many countries illegalised cannabinoid substances (Zuardi, 2006), likely due to research intoContinue reading The Use of Cannabinoids in Modern Medicine

Why is pancreatic cancer so lethal?

By Yuki Agarwala Pancreatic cancer is known to be one of the deadliest cancers in the world: in the UK, the survival rate is only 7.3% after 5 years, and drops to under 2% after 10 years (Pancreatic cancer, 2021). As the 10th most common cancer in the UK, pancreatic cancer is not extremely common,Continue reading “Why is pancreatic cancer so lethal?”

MTDL’s – The silver bullet to Alzheimers disease?

By Killian Robinson Alzheimer’s is a terrible disease that causes neurological deterioration which can often lead to other diseases like dementia. There are currently 50 million cases of Alzheimer’s worldwide which is a startling figure and is estimated to almost double every decade, with 82 million cases projected in 2030 and 152 million in 2050Continue reading “MTDL’s – The silver bullet to Alzheimers disease?”

Epigenetic remodelling drugs in cancer treatment

By Sabino Méndez Pastor There is no doubt that cancer is one of the major health burdens of our time. The World Health Organisation (World Health Organisation, 2021) estimates that it claimed 9.6 million lives in 2018, making it the second leading cause of death globally. Cancer chemotherapy has been one of the most importantContinue reading “Epigenetic remodelling drugs in cancer treatment”

The Secret to Skin Anti-Ageing

By Linya Thng  Characterized as the most voluminous organ of the body, the skin is not subject to intrinsic and extrinsic ageing. Briefly summarizing, intrinsic aging is defined by an individual’s genetic background and is dependent on time whilst extrinsic aging is influenced by environmental factors such as sun exposure, air pollution, smoking, alcohol abuse,Continue reading “The Secret to Skin Anti-Ageing”

Fighting Cancer with Bacteriophages

By Jessica Lu Bacteriophages (phages) are viruses that specifically infect and replicate in bacterial cells. Although they are bacterial viruses, phages may be used in promising new methods to fight cancer because they are easy to genetically modify and are generally regarded as non-pathogenic (Abbaszadeh et al., 2021). These methods to fight cancer generally useContinue reading “Fighting Cancer with Bacteriophages”

Malaria Vaccination: The road ahead

By Hannah Scheucher With the whole world intently watching the roll out of COVID-19 vaccines, another development in the field of vaccines is striking headlines. The WHO set a target for production of a vaccine against malaria with 75% efficacy (the % reduction of disease in vaccinated groups compared to those who are unvaccinated) –Continue reading “Malaria Vaccination: The road ahead”

Monoclonal Antibodies in Cancer Therapy

By Audrey Ko Monoclonal antibodies (mAbs) are laboratory-produced proteins that mimic the action of ordinary antibodies produced by our immune system. Since the first monoclonal antibody, Muromonab, was licensed for clinical use in 1986 (Lu et al., 2020), there has been extensive research in the therapeutic effects of these molecules. As of 2019, 80 therapeuticContinue reading “Monoclonal Antibodies in Cancer Therapy”